Chinese Medical Journal

ORIGINAL ARTICLE
Year
: 2018  |  Volume : 131  |  Issue : 16  |  Page : 1898--1903

Bone Metabolic Markers in Patients with Obstructive Sleep Apnea Syndrome


Yan Qiao1, Bei Wang1, Jiao-Jiao Yang2, Yan-Feng Fan1, Qian Guo2, Zhan-Jun Dou2, Ya-Qiong Huang2, Ting-Ting Feng2, Shu-Juan Wang2, Dong-Dong An2, Xiao-Ling Gao1 
1 Department of Respiratory and Critical Care Medicine, The Second Hospital of Shanxi Medical University, Taiyuan, Shanxi 030001, China
2 Department of the Second Clinical Medicine, Shanxi Medical University, Taiyuan, Shanxi 030001, China

Correspondence Address:
Dr. Xiao-Ling Gao
Department of Respiratory and Critical Care Medicine, The Second Hospital of Shanxi Medical University, Taiyuan, Shanxi 030001
China

Background: Obstructive sleep apnea syndrome (OSAS) is prevalent in obesity and is associated with many metabolic abnormalities. The relationship between OSAS and bone metabolism is still unclear. The aim of this study was to investigate the relationship between the severity of OSAS and bone metabolic markers. Methods: A total of 119 obese males were enrolled in this study in spring months from 2015 to 2017. All candidates underwent polysomnography, and their bone mineral density (BMD) and the serum levels of total procollagen type 1 N-terminal propeptide (t-P1NP), N-terminal midfragment of osteocalcin (N-MID), β-C-terminal telopeptide of type 1 collagen (β-CTX), vitamin D (VD), and parathyroid hormone (PTH) were measured. The analysis of variance and Pearson correlation analysis were performed for data analyses. Results: No significant differences in the mean values of BMD were observed among the obesity, mild-to-moderate OSAS, and severe OSAS groups; and the serum levels of t-P1NP and β-CTX in the severe OSAS group were significantly higher than those in the obesity group (48.42 ± 23.78 ng/ml vs. 31.98 ± 9.85 ng/ml, P < 0.001; 0.53 ± 0.24 ng/ml vs. 0.41 ± 0.13 ng/ml, P = 0.011, respectively). The serum level of VD in the obesity group was significantly higher than those in the mild-to-moderate and severe OSAS groups (both P < 0.001), and decreased as the severity of OSAS increased (P < 0.001). The serum level of PTH in the severe OSAS group was significantly higher than those in the obesity and mild-to-moderate OSAS groups (both P < 0.001). The results of correlation analysis indicated that the level of apnea-hypopnea index (AHI) was correlated with the levels of t-P1NP (r = 0.396, P < 0.001), VD (r = –0.404, P < 0.001), and PTH (r = 0.400, P < 0.001), whereas the level of minimum O2saturation (SaO2min) was correlated with the levels of VD (r = 0.258, P = 0.016) and PTH (r = –0.376, P < 0.001). Conclusions: The levels of bone resorption and formation markers in patients with severe OSAS were significantly increased compared to obese men, and the severity of OSAS was correlated with the serum levels of t-P1NP, VD, and PTH.


How to cite this article:
Qiao Y, Wang B, Yang JJ, Fan YF, Guo Q, Dou ZJ, Huang YQ, Feng TT, Wang SJ, An DD, Gao XL. Bone Metabolic Markers in Patients with Obstructive Sleep Apnea Syndrome.Chin Med J 2018;131:1898-1903


How to cite this URL:
Qiao Y, Wang B, Yang JJ, Fan YF, Guo Q, Dou ZJ, Huang YQ, Feng TT, Wang SJ, An DD, Gao XL. Bone Metabolic Markers in Patients with Obstructive Sleep Apnea Syndrome. Chin Med J [serial online] 2018 [cited 2018 Aug 14 ];131:1898-1903
Available from: http://www.cmj.org/article.asp?issn=0366-6999;year=2018;volume=131;issue=16;spage=1898;epage=1903;aulast=Qiao;type=0