Year : 2017 | Volume
: 130 | Issue : 23 | Page : 2778--2784
Plasma Neuropeptide Y Levels in Vasovagal Syncope in Children
Ying Liao1, Wen-Rui Xu1, Hong-Xia Li1, Chao-Shu Tang2, Hong-Fang Jin1, Jun-Bao Du1
1 Department of Pediatrics, Peking University First Hospital, Beijing 100034, China
2 Department of Physiology and Pathophysiology, Health Sciences Centre, Peking University, Beijing 100083, China
Background: Vasovagal syncope (VVS) is the most common cause of syncope in children. Neuropeptide Y (NPY) plays an important role in the regulation of blood pressure (BP), as well as myocardial contractility. This study aimed to explore the role of plasma NPY in VVS in children.
Methods: Fifty-six children who were diagnosed with VVS (VVS group) using head-up tilt test (HUT) and 31 healthy children who were selected as controls (control group) were enrolled. Plasma NPY concentrations were detected. The independent t-test was used to compare the data of the VVS group with those of the control group. The changes in plasma NPY levels in the VVS group during the HUT, as well as hemodynamic parameters, such as heart rate (HR), BP, total peripheral vascular resistance (TPVR), and cardiac output (CO), were evaluated using the paired t-test. Furthermore, the correlations between plasma NPY levels and hemodynamic parameters were analyzed using bivariate correlation analysis.
Results: The BP, HR, and plasma NPY (0.34 ± 0.12 pg/ml vs. 0.46 ± 0.13 pg/ml) levels in the supine position were statistically low in the VVS group compared to levels in the control group (all P < 0.05). Plasma NPY levels were positively correlated with the HR (Pearson, R = 0.395, P < 0.001) and diastolic BP (Pearson, R = 0.311, P = 0.003) when patients were in the supine position. When patients in the VVS group were in the supine position, elevated TPVR (4.6 ± 3.7 mmHg·min−1·L−1 vs. 2.5 ± 1.0 mmHg·min−1·L−1, respectively, P < 0.001; 1 mmHg = 0.133 kPa) and reduced CO (1.0 ± 0.7 L/min vs. 2.4 ± 1.3 L/min, respectively, P < 0.001) were observed in the positive-response period compared with baseline values. The plasma NPY levels were positively correlated with TPVR (Spearman, R = 0.294, P = 0.028) but negatively correlated with CO in the positive-response period during HUT (Spearman, R = −0.318, P = 0.017).
Conclusions: Plasma NPY may contribute to the pathogenesis of VVS by increasing the TPVR and decreasing the CO during orthostatic regulation.
Department of Pediatrics, Peking University First Hospital, Beijing 100034
|How to cite this article:|
Liao Y, Xu WR, Li HX, Tang CS, Jin HF, Du JB. Plasma Neuropeptide Y Levels in Vasovagal Syncope in Children.Chin Med J 2017;130:2778-2784
|How to cite this URL:|
Liao Y, Xu WR, Li HX, Tang CS, Jin HF, Du JB. Plasma Neuropeptide Y Levels in Vasovagal Syncope in Children. Chin Med J [serial online] 2017 [cited 2017 Dec 12 ];130:2778-2784
Available from: http://www.cmj.org/article.asp?issn=0366-6999;year=2017;volume=130;issue=23;spage=2778;epage=2784;aulast=Liao;type=0