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REVIEW ARTICLE
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Vitamin D and Cardiovascular Risk in Children


 Department of Pediatrics, Peking University First Hospital, Beijing 100034, China

Correspondence Address:
Jun-Bao Du,
Department of Pediatrics, Peking University First Hospital, Beijing 100034
China
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Source of Support: None, Conflict of Interest: None

Objective: Vitamin D is a group of fat-soluble molecules that are structurally similar to steroids. Emerging data have led to the hypothesis that Vitamin D plays a role in the regulation of many physiological processes beyond calcium and phosphorus homeostasis. With this review, we aimed to summarize the changes in Vitamin D levels in children with cardiovascular diseases based on the literature. In addition, we also reviewed the potential mechanisms underlying cardiovascular diseases associated with Vitamin D deficiency or insufficiency. Data Sources: The articles in English were searched from PubMed (1968–2016) and EMBASE (1991–2016), with the keywords of “Vitamin D AND cardiovascular diseases” and “Vitamin D AND children.” Study Selection: Original articles and critical reviews about Vitamin D and cardiovascular risk in children were selected for review. Researches focused on adults were excluded. Results: Studies have shown that several pediatric cardiovascular diseases may be associated with Vitamin D deficiency or insufficiency, including hypertension, orthostatic intolerance, and Kawasaki disease. Conclusions: Vitamin D may play a role in the regulation of the cardiovascular system. Further investigation would hopefully disclose the usefulness of Vitamin D as a biomarker for cardiovascular diseases in children.


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