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ORIGINAL ARTICLE
Year : 2018  |  Volume : 131  |  Issue : 8  |  Page : 894-898

Association of Source of Memory Complaints and Increased Risk of Cognitive Impairment and Cognitive Decline: A Community-Based Study


1 Department of Neurology & Institute of Neurology, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
2 Department of Rehabilitation, Shanghai Ruijin Rehabilitation Hospital, Shanghai 200023, China

Correspondence Address:
Dr. Jian-Fang Ma
Department of Neurology & Institute of Neurology, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200025
China
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0366-6999.229904

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Background: Memory complaint is common in the elderly. Recently, it was shown that self-report memory complaint was predictive of cognitive decline. This study aimed to investigate the predictive value of the source of memory complaints on the risk of cognitive impairment and cognitive decline in a community-based cohort. Methods: Data on memory complaints and cognitive function were collected among 1840 Chinese participants (aged ≥55 years old) in an urban community at baseline interview and 5-year follow-up. Incident cognitive impairment was identified based on education-adjusted Mini-Mental State Examination score. Logistic regression model was used to estimate the association between the source of memory complaints and risk of cognitive impairment conversion and cognitive decline, after adjusting for covariates. Results: A total of 1840 participants were included into this study including 1713 normal participants and 127 cognitive impairment participants in 2009. Among 1713 normal participants in 2009, 130 participants were converted to cognitive impairment after 5 years of follow-up. In 2014, 606 participants were identified as cognitive decline. Both self- and informant-reported memory complaints were associated with an increased risk of cognitive impairment (odds ratio [OR] = 1.60, 95% confidence interval [CI]: 1.04–2.48) and cognitive decline (OR = 1.30, 95% CI: 1.01–1.68). Furthermore, this association was more significant in males (OR = 2.10, 95% CI: 1.04–4.24 for cognitive impairment and OR = 1.87, 95% CI: 1.20–2.99 for cognitive decline) and in higher education level (OR = 1.79, 95% CI: 1.02–3.15 for cognitive impairment and OR = 1.40, 95% CI: 1.02–1.91 for cognitive decline). Conclusions: Both self- and informant-reported memory complaints were associated with an increased risk of cognitive impairment conversion and cognitive decline, especially in persons with male gender and high educational background.

 

 Abstract in Chinese

记忆主诉来源与认知障碍和记忆减退的风险增加相关:来自于社区的研究

摘要

研究背景:老年人多诉记忆力减退,研究发现记忆力减退的主诉是认知功能减退的预测因素。本研究旨在探究不同来源的记忆主诉对认知障碍和认知功能减退风险的预测作用。
研究方法:本研究收集了1840名中国城市社区老年人(年龄≥55岁)基线和随访5年后的记忆主诉和记忆功能数据。用简易智能量表(MMSE)评估其认知功能。应用Logistic回归模型在调整相关因素之后分析不同来源的认知主诉与认知功能障碍和认知功能减退的关系。
研究结果:在2009年共纳入1840名社区老人,在基线1713人认知正常,另127人有认知功能障碍。随访5年后,基线认知功能正常的1713人中有130人转变为认知功能障碍。同时发现有606人认知功下降。结果显示自诉和家人诉的记忆力减退都是认知功能障碍(OR=1.60, 95% CI: 1.04–2.48)和认知功能下降(OR=1.30, 95% CI: 1.01–1.68)的危险因素。进一步分析发现在男性和教育水平较高的人群中自诉和家人诉的记忆力减退与认知功能障碍和认知功能下降的关系更大(男性:认知功障碍OR=2.10, 95% CI: 1.04–4.24;认知功能下降OR=1.87, 95% CI: 1.20–2.99;高教育水平人群:认知功障碍OR=1.79, 95% CI: 1.02–3.15;认知功能下降OR=1.40, 95% CI: 1.02–1.91)。
研究结论:自诉和家人诉的记忆力减退与认知功能障碍转归和认知功能进行性下降有关,尤其在在男性和高教育水平人群中其与认知功能障碍和下降的关系更为密切。



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