Home About us Articles Multimedia Search Instructions Login 
IF 2017: 1.596 (® Clarivate Analytics)
Total Cites: 7606
Q2 in Medicine, General & Internal
Follow Us
Follow Us
  • Users Online: 3467
  • Home
  • Print this page
  • Email this page
REVIEW ARTICLE
Year : 2018  |  Volume : 131  |  Issue : 19  |  Page : 2338-2345

Common Injuries and Repair Mechanisms in the Endothelial Lining


1 Department of Neurology, Beijing Hospital, National Center of Gerontology, Beijing 100730, China
2 National Center for Clinical Laboratories, Beijing Hospital, National Center of Gerontology, Beijing 100730, China
3 Department of Internal Medicine, Jinzhou Medical University, Jinzhou, Liaoning 121001, China

Correspondence Address:
Tao Gong
Department of Neurology, Beijing Hospital, National Center of Gerontology, No. 1 Dahua Road, Dong Dan, Beijing 100730
China
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0366-6999.241805

Rights and Permissions

Objective: Endothelial cells (ECs) are important metabolic and endocrinal organs which play a significant role in regulating vascular function. Vascular ECs, located between the blood and vascular tissues, can not only complete the metabolism of blood and interstitial fluid but also synthesize and secrete a variety of biologically active substances to maintain vascular tension and keep a normal flow of blood and long-term patency. Therefore, this article presents a systematic review of common injuries and healing mechanisms for the vascular endothelium. Data Sources: An extensive search in the PubMed database was undertaken, focusing on research published after 2003 with keywords including endothelium, vascular, wounds and injuries, and wound healing. Study Selection: Several types of articles, including original studies and literature reviews, were identified and reviewed to summarize common injury and repair processes of the endothelial lining. Results: Endothelial injury is closely related to the development of multiple cardiovascular and cerebrovascular diseases. However, the mechanism of vascular endothelial injury is not fully understood. Numerous studies have shown that the mechanisms of EC injury mainly involve inflammatory reactions, physical stimulation, chemical poisons, concurrency of related diseases, and molecular changes. Endothelial progenitor cells play an important role during the process of endothelial repair after such injuries. What's more, a variety of restorative cells, changes in cytokines and molecules, chemical drugs, certain RNAs, regulation of blood pressure, and physical fitness training protect the endothelial lining by reducing the inducing factors, inhibiting inflammation and oxidative stress reactions, and delaying endothelial caducity. Conclusions: ECs are always in the process of being damaged. Several therapeutic targets and drugs were seeked to protect the endothelium and promote repair.

 

 Abstract in Chinese

血管内皮细胞的普遍状态:修复与损伤的抗衡

摘要

目的:内皮细胞是重要的代谢和内分泌器官,在调节血管功能方面起着重要的作用。血管内皮细胞位于血液和血管组织之间,不仅可以完成血液和组织液的新陈代谢,而且可以合成和分泌多种生物活性物质,以保持血管紧张度,维持正常的血液流动和长期通畅。因此,本文系统地综述了血管内皮细胞的普遍状态:修复与损伤的抗衡。

方法:通过计算机检索Pubmed数据库,搜索了2003年以后发表的相关研究论文,文章关键词包括“内皮细胞”、“血管”、“损伤”、“修复”。

结果:多种心脑血管疾病的发生发展与内皮细胞的损伤密切相关。然而,血管内皮细胞损伤的机制尚不完全清楚。大量研究表明,内皮细胞损伤的机制主要涉及炎症反应、物理刺激、化学毒物和分子改变。内皮祖细胞在损伤后的内皮细胞修复过程中起着重要作用。此外,多种具有修复功能的细胞、细胞因子和分子的变化、药物、某些RNA、血压调节和体能训练都对内皮细胞有保护作用,其作用是通过减弱诱发因素、抑制炎症和氧化应激反应、延缓内皮细胞衰老来实现的。

结论:内皮细胞一直处于损伤和抗损伤的过程中。鉴于内皮细胞在脑血管病发展中的重要作用,人们正在寻找保护内皮细胞和促进内皮细胞修复的治疗靶点和药物。



[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed128    
    Printed0    
    Emailed0    
    PDF Downloaded30    
    Comments [Add]    

Recommend this journal

 

京ICP备05052599号