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ORIGINAL ARTICLE
Year : 2018  |  Volume : 131  |  Issue : 18  |  Page : 2172-2178

Combined Effects of Electroacupuncture and Behavioral Training on Learning-Memory Ability and Event-Related Potential P300 in Rats with Mid/Advanced Cerebral Infarction


1 Department of Rehabilitation Medicine, Sichuan Academy of Medical Sciences, Sichuan Provincial People's Hospital, Chengdu, Sichuan 610072, China
2 Department of Neurology, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan 646000, China
3 Department of Rehabilitation Medicine, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan 646000, China
4 Electrophysiology Room of Department of Neurology, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan 646000, China

Correspondence Address:
Prof. Qian Yu
Department of Rehabilitation, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, 1 Huapaifang Street, Chengdu, Sichuan 610072
China
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0366-6999.240799

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Background: The effectiveness of the combination of electroacupuncture (EA) and behavioral training (BT) for mid/advanced cerebral infarction (M/ACI) and related mechanisms remains unclear. This study aimed to investigate the combined effects on the learning-memory ability and event-related potential P300 in rats with M/ACI. Methods: Eighty rats with M/ACI were divided into Group Model (M), Group EA, Group BT, and Group EA-BT (n = 20) according to the random number with five healthy rats in Group Control (CON). On the 6th week after modeling, EA, BT, and EA-BT were given to Group EA, Group BT, and Group EA-BT, respectively, whereas Group M and Group CON were not given any intervention. Y-maze test and P300 were recorded before and after the intervention. Results: After intervention, the P300 latency was lower and the amplitude was higher in the Group EA-BT, Group EA, and Group BT than before (for latency, t = −7.638, −4.334, and −5.916; for amplitude, t = 8.125, 3.846, and 5.238; P < 0.01), with Group EA-BT superior to Group EA (for latency, t = −3.708; for amplitude, t = 3.653; P < 0.01) and Group BT (for latency, t = −2.067; for amplitude, t = 2.816; P < 0.05), with no significant difference between Group BT and EA (for latency, t = −1.439; for amplitude, t = 1.075; P > 0.05). While the performances of Y-maze tests in the Group EA-BT, Group EA, and Group BT were all better than before (t = 10.359, 4.520, and 7.791, P < 0.01), with Group EA-BT better than Group EA (t = 5.627, P < 0.01) and Group BT (t = 2.913, P < 0.01) respectively, and Group BT better than Group EA (t = 2.912, P < 0.01). Conclusion: EA or BT can affect P300 in rats with M/ACI, and the combination of these two methods can significantly improve the learning-memory ability.

 

 Abstract in Chinese

电针结合行为训练对脑梗死中晚期大鼠学习记忆能力和事件相关电位P300的影响

摘要

背景: 电针结合行为训练对中晚期脑梗死的影响及相关机制仍不清楚,本研究的目的是探讨电针结合行为训练对脑梗死中晚期大鼠学习记忆能力和事件相关电位P300的影响。

方法: 80只脑梗死中晚期大鼠按随机数字表法分成模型组、电针组、训练组、联合组,每组各20只;对照组为5只健康大鼠。于造模后第6天,分别给予电针组、训练组、联合组以电针、行为训练、电针+行为训练,而模型组和对照组不给予任何干预。分别于干预前后记录Y-迷宫分辨学习能力和P300。

结果: 干预后,联合组、电针组、训练组P300与干预前比较其潜伏期均减小,波幅均增大(潜伏期:t = −7.638, −4.334, −5.916;波幅: t = 8.125, 3.846, 5.238;P < 0.01);且联合组优于电针组(潜伏期:t = −3.708;波幅:t = 3.653;P < 0.01)和训练组(潜伏期:t = −2.067;波幅:t = 2.816;P < 0.05),而电针组和训练组之间差异无统计学意义(潜伏期:t = −1.439;波幅:t = 1.075; P > 0.05)。Y-迷宫结果显示联合组、电针组、训练组学习记忆能力分别较干预前改善(t = 10.359, 4.520, 7.791,P < 0.01),且联合组优于电针组(t = 5.627, P < 0.01) 和训练组(t = 2.913, P < 0.01),训练组优于电针组(t = 2.912, P < 0.01)。

结论: 电针或行为训练均影响脑梗死中晚期大鼠P300,两者联合使用可显著提高学习记忆能力。



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