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Year : 2017  |  Volume : 130  |  Issue : 9  |  Page : 1012-1018

Relationship between Oral Glucose Tolerance Test Characteristics and Adverse Pregnancy Outcomes among Women with Gestational Diabetes Mellitus

1 Department of Obstetrics and Gynecology, Peking University First Hospital, Beijing 100034, China
2 Department of Obstetrics and Gynecology, Peking University First Hospital, Beijing 100034; Exchange and Cooperation Division, National Institute of Hospital Administration, Beijing 100191, China
3 Helen Schneider Hospital for Women, Rabin Medical Center, Sackler Faculty of Medicine, Tel-Aviv University, Petah-Tiqva, Tel-Aviv 6997801, Israel

Correspondence Address:
Prof. Hui-Xia Yang
Department of Obstetrics and Gynecology, Peking University First Hospital, Beijing 100034
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0366-6999.204928

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Background: Hyperglycemia is associated with adverse pregnancy outcomes. However, the relationships between them remain ambiguous. This study aimed to analyze the effect of different oral glucose tolerance test (OGTT) results on adverse perinatal outcomes. Methods: This retrospective cohort study included data from 15 hospitals in Beijing from June 20, 2013 to November 30, 2013. Women with gestational diabetes mellitus (GDM) were categorized according to the number and distribution of abnormal OGTT values, and the characteristics of adverse pregnancy outcomes were evaluated. Chi-square test and logistic regression analysis were used to determine the associations. Results: In total, 14,741 pregnant women were included in the study population, 2927 (19.86%) of whom had GDM. As the number of hyperglycemic values in the OGTT increased, the risk of cesarean delivery, preterm births, large-for-gestational age (LGA), macrosomia, and neonatal complications significantly increased. Fasting hyperglycemia had clear associations with macrosomia (odds ratios [OR s]:1.84, 95% confidence intervals [CI s]: 1.39–2.42,P < 0.001), LGA (OR: 1.70, 95% CI: 1.29–2.25,P < 0.001), and cesarean delivery (OR: 1.33, 95% CI: 1.15–1.55,P < 0.001). The associations were stronger as fasting glucose increased. GDM diagnosed by hyperglycemia at OGTT-2 h was more likely to lead to preterm birth (OR: 1.50, 95% CI: 1.11–2.03,P < 0.01). Conclusions: Various characteristics of OGTTs are associated with different adverse outcomes. A careful reconsideration of GDM with hierarchical and individualized management according to OGTT characteristics is needed.

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