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 Table of Contents  
CORRESPONDENCE
Year : 2017  |  Volume : 130  |  Issue : 23  |  Page : 2897-2898

Nevus Sebaceous at an Unusual Location: A Rare Presentation


1 Department of Pathology, Tianjin Academy of Traditional Chinese Medicine Affiliated Hospital, Tianjin 300120, China
2 Department of Dermatology, Tianjin Academy of Traditional Chinese Medicine Affiliated Hospital, Tianjin 300120, China

Date of Submission05-Sep-2017
Date of Web Publication24-Nov-2017

Correspondence Address:
Li-Tao Zhang
Department of Dermatology, Tianjin Academy of Traditional Chinese Medicine Affiliated Hospital, 354 Beima Road, Hongqiao District, Tianjin 300120
China
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0366-6999.219147

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How to cite this article:
Gu AK, Zhang XJ, Zhang LT, Ma FK. Nevus Sebaceous at an Unusual Location: A Rare Presentation. Chin Med J 2017;130:2897-8

How to cite this URL:
Gu AK, Zhang XJ, Zhang LT, Ma FK. Nevus Sebaceous at an Unusual Location: A Rare Presentation. Chin Med J [serial online] 2017 [cited 2017 Dec 12];130:2897-8. Available from: http://www.cmj.org/text.asp?2017/130/23/2897/219147



To the Editor: Nevus sebaceous (NS) is an epidermal nevus that is comprised predominantly of sebaceous glands in approximately 0.3% of newborns.[1] Clinically, it presents as a single or, less commonly, multiple yellowish-colored plaques with overlying alopecia, usually confined on the scalp; however, it can also appear on the face, preauricular area, and neck region.[2],[3] Here, we reported a case of NS in a discrete linear pattern located on the left chest region, in contrast with typical cases, to assist physicians in the early diagnosis of this condition and to prevent unnecessary examinations and inadequate therapeutic interventions.

A 38-year-old female presented with a few localized, yellowish, and slightly verrucous growth lesions on her left chest for more than 20 years [Figure 1]a. The lesions were nonprogressive, both in size and extent, except for proportional increase with body size. The patient wanted to have the lesions removed for cosmetic reasons. Cutaneous examination showed that the lesions were several separate purples and small plaques arranged in a discrete linear pattern on her left chest. They were round or irregularly shaped with clear boundaries with normal skin and size of 0.5–1.5 cm. Moreover, lesions were soft on palpation and did not exhibit any subjective. The patient had no associated systemic abnormalities, such as seizures, vision or hearing impairment, or skeletal deformities, except for the abovementioned lesions. Laboratory tests, including routine hematological examination, liver and renal function tests, and serum lipids and sugar level, were all normal. Chest and skull radiographs and abdominal ultrasonography revealed no abnormalities. Biopsy was taken from the bottom of the lesion, and histological examination revealed a large number of mature sebaceous glands, slight papillomatosis with hyperkeratosis, and acanthosis of the epidermis [Figure 1]b. In the dermis, parts of sebaceous glands were connected to the overlying epidermis [Figure 1]c. A final diagnosis of NS was made based on the clinical and histopathological findings. The purples and small plaques were cut off, respectively, with the least scar (cosmetic reasons) and did not recur 5 months after the surgery.
Figure 1: Clinical and histopathological findings of a 38-year-old female with nevus sebaceous. (a) Clinical examination demonstrated several separate purples and small plaques arranged in a discrete linear pattern on her left chest. They were round or irregularly shaped with circumscribed boundaries with normal skin and size of 0.5–1.5 cm. (b) Histopathological findings showed a large numbers of mature sebaceous glands, slight papillomatosis with hyperkeratosis, and acanthosis of the epidermis (H&E staining, ×40). (c) In the dermis, parts of sebaceous glands were connected to the overlying epidermis (H&E staining, ×100).

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NS is a type of organoid nevus. Classically, it presents at infancy as a single bald patch over the scalp and generally remains unchanged until puberty after which the patch becomes more thickened and protuberant and at times verrucous or nodular, with a smooth velvety surface.[1] Among 202 cases of Chi et al.,[2] the most common site of NS was the scalp (66.8%), followed by the face (26.7%) and the neck (5.5%). However, NS may also be present at other sites, such as the trunk or mucosae,[3],[4],[5] or have an atypical morphology. In a case, NS was located on the back as a part of an extensive NS with velvety appearance.[1] However, in our case, the patient presented a rare morphological variant of NS with discrete linear growth appearance on the chest (a morphology of several separate purples and small plaques), which was different from the classic presentation. NS that can be associated with other syndromic features such as mental retardation, central nervous system abnormalities, oculocardiac defects, or skeletal abnormalities is called linear NS syndrome, or Schimmelpenning syndrome (a neurocutaneous phakomatosis).[6] In this case, no involvement of oral and genital mucosae was seen. No multisystem disorders, such as neurological, ophthalmological, and skeletal abnormalities, were associated with the linear sebaceous nevus syndrome.

Declaration of patient consent

The authors certify that they have obtained all appropriate patient consent forms. In the form the patient(s) has/have given his/her/their consent for his/her/their images and other clinical information to be reported in the journal. The patients understand that their names and initials will not be published and due efforts will be made to conceal their identity, but anonymity cannot be guaranteed.

Financial support and sponsorship

Nil.

Conflicts of interest

There are no conflicts of interest.



 
  References Top

1.
Mahajan R, Dogra S, Kanwar AJ, Saikia UN, Agrawal S. Extensive cerebriform nevus sebaceus: An unusual presentation. Dermatol Online J 2012;18:9.  Back to cited text no. 1
[PUBMED]    
2.
Chi SG, Kim JY, Kim HY, Lee SJ, Kim DW, Lee WJ, et al. Multiple nevus sebaceous occurring on the scalp and on the contralateral side of the face. Ann Dermatol 2011;23:389-91. doi: 10.5021/ad.2011.23.3.389.  Back to cited text no. 2
    
3.
Ugras N, Ozgun G, Adim SB, Ozerkan K. Nevus sebaceous at unusual location: A rare presentation. Indian J Pathol Microbiol 2012;55:419-20. doi: 10.4103/0377-4929.101768.  Back to cited text no. 3
  [Full text]  
4.
Suyama T, Yokoyama M, Teraki Y, Izaki S. Case of squamous cell carcinoma arising within a linear nevus sebaceus on the trunk. J Dermatol 2016;43:1236-7. doi: 10.1590/abd1806-4841.20164506.  Back to cited text no. 4
[PUBMED]    
5.
Kavak A, Ozcelik D, Belenli O, Buyukbabani N, Saglam I, Lazova R, et al. Aunique location of naevus sebaceus: Labia minora. J Eur Acad Dermatol Venereol 2008;22:1136-8. doi: 10.1111/j.1468-3083.2007.02552.x.  Back to cited text no. 5
    
6.
Wang SM, Hsieh YJ, Chang KM, Tsai HL, Chen CP. Schimmelpenning syndrome: A case report and literature review. Pediatr Neonatol 2014;55:487-90. doi: 10.1016/j.pedneo.2012.12.017.  Back to cited text no. 6
[PUBMED]    


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