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ORIGINAL ARTICLE
Year : 2017  |  Volume : 130  |  Issue : 20  |  Page : 2416-2422

A Bayesian Stepwise Discriminant Model for Predicting Risk Factors of Preterm Premature Rupture of Membranes: A Case-control Study


1 Department of Microbiology and Immunology, Health Science Center, Xi'an Jiaotong University, Xi'an, Shaanxi 710061; Deparment of Clinical Laboratory, Shaanxi Provincial People's Hospital, Xi'an, Shaanxi 710068, China
2 Department of Medical Statistics, Shaanxi Provincial People's Hospital, Xi'an, Shaanxi 710068, China
3 Deparment of Clinical Laboratory, Shaanxi Provincial People's Hospital, Xi'an, Shaanxi 710068, China
4 Deparment of Clinical Laboratory, Xi'an Fourth Hospital, Xi'an, Shaanxi 710004, China
5 Deparment of Clinical Laboratory, Xi'an Gaoxin Hospital, Xi'an, Shaanxi 710075, China
6 Deparment of Clinical Laboratory, Chang'an Hospital, Xi'an, Shaanxi 710018, China
7 Department of Obstetrics and Gynecology, The Northwest Women and Children Hospital, Xi'an, Shaanxi 710061, China
8 Department of Microbiology and Immunology, Health Science Center, Xi'an Jiaotong University, Xi'an, Shaanxi 710061, China

Correspondence Address:
Ji-Ru Xu
Department of Microbiology and Immunology, Health Science Center, Xi'an Jiaotong University, Xi'an, Shaanxi 710061
China
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0366-6999.216396

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Background: Preterm premature rupture of membrane (PPROM) can lead to serious consequences such as intrauterine infection, prolapse of the umbilical cord, and neonatal respiratory distress syndrome. Genital infection is a very important risk which closely related with PPROM. The preliminary study only made qualitative research on genital infection, but there was no deep and clear judgment about the effects of pathogenic bacteria. This study was to analyze the association of infections with PPROM in pregnant women in Shaanxi, China, and to establish Bayesian stepwise discriminant analysis to predict the incidence of PPROM. Methods: In training group, the 112 pregnant women with PPROM were enrolled in the case subgroup, and 108 normal pregnant women in the control subgroup using an unmatched case-control method. The sociodemographic characteristics of these participants were collected by face-to-face interviews. Vaginal excretions from each participant were sampled at 28–36+6 weeks of pregnancy using a sterile swab. DNA corresponding to Chlamydia trachomatis (CT), Ureaplasma urealyticum (UU), Candida albicans, group B streptococci (GBS), herpes simplex virus-1 (HSV-1), and HSV-2 were detected in each participant by real-time polymerase chain reaction. A model of Bayesian discriminant analysis was established and then verified by a multicenter validation group that included 500 participants in the case subgroup and 500 participants in the control subgroup from five different hospitals in the Shaanxi province, respectively. Results: The sociological characteristics were not significantly different between the case and control subgroups in both training and validation groups (all P > 0.05). In training group, the infection rates of UU (11.6% vs. 3.7%), CT (17.0% vs. 5.6%), and GBS (22.3% vs. 6.5%) showed statistically different between the case and control subgroups (all P < 0.05), log-transformed quantification of UU, CT, GBS, and HSV-2 showed statistically different between the case and control subgroups (P < 0.05). All etiological agents were introduced into the Bayesian stepwise discriminant model showed that UU, CT, and GBS infections were the main contributors to PPROM, with coefficients of 0.441, 3.347, and 4.126, respectively. The accuracy rates of the Bayesian stepwise discriminant analysis between the case and control subgroup were 84.1% and 86.8% in the training and validation groups, respectively. Conclusions: This study established a Bayesian stepwise discriminant model to predict the incidence of PPROM. The UU, CT, and GBS infections were discriminant factors for PPROM according to a Bayesian stepwise discriminant analysis. This model could provide a new method for the early predicting of PPROM in pregnant women.


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