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ORIGINAL ARTICLE
Year : 2016  |  Volume : 129  |  Issue : 7  |  Page : 757-762

Clinical Features of Adult/Adolescent Atopic Dermatitis and Chinese Criteria for Atopic Dermatitis


1 Department of Dermatology, Peking University People's Hospital, Beijing 100044, China
2 Department of Dermatology, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, China
3 Department of Dermatology, The First Hospital of China Medical University, Shenyang, Liaoning 110001, China
4 Department of Dermatology, Institute of Dermatology, Chinese Academy of Medical Sciences, Nanjing, Jiangsu 210042, China
5 Department of Dermatology, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang 310009, China
6 Department of Dermatology, Tianjin Changzheng Hospital, Tianjin 300120, China
7 Department of Dermatology, The Affiliated Hospital of Inner Mongolia Medical University, Hohhot, Inner Mongolia 010050, China
8 Department of Dermatology, Yantai Yuhuangding Hospital, Yantai, Shandong 264000, China
9 Department of Dermatology, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi 530021, China
10 Department of Dermatology, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150001, China
11 Department of Dermatology, The Second Hospital of Dalian Medical University, Dalian, Liaoning 116023, China
12 Department of Dermatology, Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China
13 Department of Dermatology, Shanghai Huashan Hospital, Shanghai 200040, China
14 Department of Dermatology, Xijing Hospital, Xi'an, Shaanxi 710032, China
15 Department of Dermatology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510630, China
16 Department of Dermatology, The Second Hospital of Heilongjiang Province, Harbin, Heilongjiang 150010, China
17 Department of Dermatology, Xiangya Hospital of Central South University, Changsha, Hunan 410008, China
18 Department of Dermatology, Shengjing Hospital of China Medical University, Shenyang, Liaoning 110004, China
19 Department of Dermatology, Peking University Third Hospital, Beijing 100191, China
20 Department of Dermatology, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650032, China
21 Department of Dermatology, West China Hospital of Sichuan University, Chengdu, Sichuan 610041, China
22 Department of Dermatology, The Second Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650101, China
23 Department of Dermatology, Qingdao Municipal Hospital, Qingdao, Shandong 266011, China

Correspondence Address:
Jian-Zhong Zhang
Department of Dermatology, Peking University People's Hospital, Beijing 100044
China
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0366-6999.178960

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Background: Atopic dermatitis (AD) is an inflammatory skin disease characterized by chronic recurrent dermatitis with profound itching. Most patients have personal and/or family history of atopic diseases. Several criteria have been proposed for the diagnosis of AD. Although the clinical features of childhood AD have been widely studied, there has been less large-scale study on adult/adolescent AD. The aim of this study was to investigate the clinical features of adult/adolescent patients with chronic symmetrical eczema/AD and to propose Chinese diagnostic criteria for adult/adolescent AD. Methods: A hospital-based study was performed. Forty-two dermatological centers participated in this study. Adult and adolescent patients (12 years and over) with chronic symmetrical eczema or AD were included in this study. Questionnaires were completed by both patients and investigators. The valid questionnaires were analyzed using EpiData 3.1 and SPSS 17.0 software. Results: A total of 2662 valid questionnaires were collected (1369 male and 1293 female). Of all 2662 patients, 2062 (77.5%) patients had the disease after 12 years old, while only 600 (22.5%) patients had the disease before 12 years old, suggesting late-onset eczema/AD is common. Two thousand one hundred and thirty-nine (80.4%) patients had the disease for more than 6 months. One thousand one hundred and forty-four (43.0%) patients had a personal and/or family history of atopic diseases. One thousand five hundred and forty-eight (58.2%) patients had an elevated total serum IgE and/or eosinophilia and/or positive allergen-specific IgE. Based on these clinical and laboratory features, we proposed Chinese criteria for adult/adolescent AD. Of all 2662 patients, 60.3% were satisfied with our criteria, while only 48.2% satisfied with Hanifin Rajka criteria and 32.7% satisfied with Williams criteria, suggesting a good sensitivity of our criteria in adult/adolescent AD patients. Conclusion: Late-onset of eczema or AD is common. The clinical manifestations of AD are heterogeneous. We have proposed Chinese diagnostic criteria for adolescent and adult AD, which are simple and sensitive for diagnosis of adult/adolescent AD.


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