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ORIGINAL ARTICLE
Year : 2015  |  Volume : 128  |  Issue : 12  |  Page : 1655-1661

Biomechanical and Macroscopic Evaluations of the Effects of 5-Fluorouracil on Partially Divided Flexor Tendon Injuries in Rabbits


1 Department of Plastic and Reconstructive Surgery, University Clinical Center of Kosovo, Prishtina 10000, Kosovo
2 Department of Pediatric Surgery, University Clinical Center of Kosovo, Prishtina 10000, Kosovo
3 Institute of Pathology, University Clinical Center of Kosovo, Prishtina 10000, Kosovo
4 Institute of Pathophysiology, University Clinical Center of Kosovo, Prishtina 10000, Kosovo
5 Department of Neurosurgery, University Clinical Center of Kosovo, Prishtina 10000, Kosovo
6 Faculty of Mechanical Engineering, University of Prishtina, Prishtina 10000, Kosovo

Correspondence Address:
Hasan R Ahmeti
Department of Pediatric Surgery, University Clinical Center of Kosovo, Rrethi i Spitalit p.n. 10000 Prishtina
Kosovo
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0366-6999.158367

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Background: The main goals of flexor tendon surgery are to restore digital motion by providing tendon healing and to preserve tendon gliding. Our purpose was to investigate the effects of 5-fluorouracil (5-FU) on tendon adhesions in partially divided profundus flexor tendons (flexor digitorum profundus [FDPs]) following surgical repair and in partially divided FDPs without surgical repair, and to compare the results of the repair versus the nonrepair of zone two injuries via macroscopic and biomechanical evaluations of tendon adhesions. Methods: We used 32 adult male European rabbits (Oryctolagus cunniculus) weighing from 2.5 to 3.5 kg. The study was performed on the deep flexor tendons of the second and third digits of the right hind paws of the rabbits; thus, a total of 64 tendons were examined in this study. Results: Based on the results achieved in our experimental study, the load (N) significantly increased in subgroup 1a in which the tendons were surgically repaired and were not treated with 5-FU compared with subgroup 2a in which tendons were surgically repaired and treated with 5-FU. Conclusions: The load (N) significantly increased in subgroup 1a in which the tendons were surgically repaired and were not treated with 5-FU compared to subgroup 2a in which the tendons were surgically repaired and treated with 5-FU. Therefore, these results revealed a decrease in adhesion formation in the subgroup that was treated with 5-FU due to increased resistance to tendon adhesions during their excursion through the tendon sheath, which in this case required greater traction force.


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